12 Hour Shift is a 2020 American black comedy horror film written and directed by Brea Grant and starring Angela Bettis, Kit Williamson, and David Arquette. Bettis plays Mandy, a drug-addicted nurse involved in a black market organ-trading scheme in 1999. Arquette was one of the film's producers, alongside his wife Christina Arquette, and Jordan Wayne Long, Tara Perry, and Matt Glass. The film also features music composed by Glass.
12 Hour Shift was scheduled to have its world premiere at the Tribeca Film Festival in April 2020 prior to the festival being postponed due to the COVID-19 pandemic. The film's distribution rights were acquired by Magnet Releasing in June 2020.
In Arkansas in 1999, Mandy is an overworked nurse with a drug addiction. In addition to stealing patient medications, she finances her drug habit by harvesting patient organs. Desk nurse Karen is Mandy's partner, and Mandy has recently brought on her cousin Regina to transport the organs to trafficker Nicholas.
One night, at the start of her 12 hour shift, Mandy hands over a harvested kidney in cooler to Regina behind the hospital. Regina accidentally leaves the cooler with the kidney, instead carrying a cooler with a soda can to Nicholas. Nicholas demands Regina get the kidney or he will take hers. Regina cannot find the kidney at the hospital. Mandy refuses to help her, so Regina dresses like a nurse and kills one of Mandy's patients by pouring bleach down his throat. Regina expects that Mandy will be able to extract the dead patient's kidney, but Mandy angrily explains that he was on dialysis, so his kidneys are useless.
Police arrive to investigate the murdered patient. Regina attacks more people and threatens to expose the organ trafficking operation unless Mandy helps her. Mandy agrees and tells Regina to wait outside. Regina sees one of Nicholas's henchman, and in a panic kills a passing skateboarder and to take his kidney, but ends up taking his bladder instead. Meanwhile, inside the hospital Mandy kills a patient with an overdose and manages to harvest his kidney. She leaves the kidney in another cooler by the vending machine, but it has disappeared by the time Regina gets to it.
Nicholas's henchman, who has entered the hospital and terrorized staff and patients, prepares to drag Regina away, but she desperately suggests that they kidnap a comatose patient so that Nicholas can take all his organs. The comatose patient is Mandy's abusive, drug-addicted half-brother. Mandy intervenes, and together she and Regina manage to overcome the henchman. The police investigation (incorrectly) determines that the henchman had been committing the murders around the hospital. Regina leaves. A hospital guest suddenly announces that he has been finding the coolers containing kidneys all night; the exhausted Mandy leaves to take a nap in her truck. The film ends with Mandy re-entering the hospital to begin her next shift, followed shortly thereafter by Nicholas.